A Multi-Locus Approach to Treating Fibromyalgia by Boosting Dopaminergic Activity in the Meso-Limbic System of the Brain
نویسندگان
چکیده
Fibromyalgia (FM), is associated with fatigue, chronic diffuse pain, and cognitive/mood disturbances [1,2]. FM patients have greater healthcare costs and reduced workplace productivity. Stress and the neurotransmitter dopamine may interact, and this interaction may induce FM. Interestingly, FM has been called a ‘stress-related disorder’ presenting an exacerbation of symptoms on the context of stressful events [3].
منابع مشابه
Using BELBIC based optimal controller for omni-directional threewheel robots model identified by LOLIMOT
In this paper, an intelligent controller is applied to control omni-directional robots motion. First, the dynamics of the three wheel robots, as a nonlinear plant with considerable uncertainties, is identified using an efficient algorithm of training, named LoLiMoT. Then, an intelligent controller based on brain emotional learning algorithm is applied to the identified model. This emotional l...
متن کاملEpilepsy and dopaminergic system
Epilepsy is accompanied with a strong change in neuronal activity not only in excitatory (glutamatergic) and inhibitory (GABAergic) neurotransmission, but also in neuromodulatory agents. Dopaminergic system, as an important neuromodulatory system of the brain, has significant effect on neuronal excitability. In addition, this system undergoes many changes in epileptic brain. Understanding the e...
متن کاملThe effects of locus coeruleus electrical stimulation on brain waves of morphine dependent rats
Introduction: Opiates cause dependency via affect on central nervous system. Locus coeruleus nucleus is a main group of noradrenergic neurons in the brain that plays an important role in the expression of opioid withdrawal signs. During opioid withdrawal, brain waves change in addition to physical and behavioral signs. In this study, we examined the effects of locus coeruleus electrical sti...
متن کاملElectroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain
Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used...
متن کاملP28: The Effects of Omega-3 and 6 Fatty Acids on Hippocampus and Learning
One of the most nervous system evolution are memory and learning in humans. Learning is a skill that enhances synaptic activity in the hippocampus of prefrontal cortex. In fact, basic passive learning is communication between the conditioned and Unconditioned stimulation. Passive learning involves three steps: habit, education and remember. According to the results of investigations, the hippoc...
متن کامل